解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The association of [3H] [D-Ala2, D-Leu5] enkephalin ([3H]DADLE]) with mouse neuroblastoma cells (N4TG1) was investigated. Under identical conditions the time course, dose response curve and temperature dependence for ligand uptake were similar to those for ligand-induced receptor loss (down regulation). Uptake of [3H]...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90369-1
更新日期:1982-09-20 00:00:00
abstract::Tifluadom, although structurally a 1,4 benzodiazepine, has no affinity for the 3H-flunitrazepam binding site, but is a potent displacer of 3H-bremazocine from its opioid binding site. Tifluadom is characterised as an opiate kappa-receptor agonist in vitro and in vivo with potent analgesic activity in animals and no de...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90346-0
更新日期:1982-09-20 00:00:00
abstract::Male and female rats with two permanently indwelling intravenous catheters were infused for 2 hours with ovine prolactin. During equilibrium conditions the effects of intravenously injected L-DOPA and benzerazide (a blocker of dopa-decarboxylase) on steady state levels of ovine prolactin were measured. A dose of 4.5 m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90549-5
更新日期:1982-08-30 00:00:00
abstract::Initial acute behavioral studies in mice indicated that phencyclidine (PCP) produced marked motor impairment as measured by the inverted screen technique with an ED50 value of 4.1 muMole/kg (i.v.). Phenylcyclohexene (PC) was considerably less active with an ED50 value of 325 muMole/kg (i.v.). PCP was also shown to be ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90708-1
更新日期:1982-08-23 00:00:00
abstract::This review is an attempt to establish a role for both glucocorticoid and thyroid hormones in the aging process as factors which mediate the regulation of transcription and translation of specific genetic domains. Furthermore, through a review of the current knowledge of the effect of long-term hypophysectomy on physi...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(82)90762-7
更新日期:1982-08-16 00:00:00
abstract::The changes in the energy charge (ATP + 0.5 ADP)/(ATP + ADP + AMP) levels of the remnant liver were studied in relation to changes in the incorporation rate of methyl-3H-thymidine into DNA, the blood ratio of acetoacetate/beta-hydroxybutyrate and indocyanine green (ICG) clearance in 70% hepatectomized rabbits. The ene...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90765-2
更新日期:1982-08-16 00:00:00
abstract::Tissue copper levels of brindled (Mobr) mice and normal litter-mates after single and repeated dosing with CuCl2 and/or D-penicillamine are examined, together with a study of the cytosol distribution of copper after CuCl2 treatment. The results confirm that the mutant mouse kidney is capable of extensive copper accumu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90326-5
更新日期:1982-08-02 00:00:00
abstract::The effects of naloxone or thyrotropin releasing hormone (TRH) upon neurologic outcome were evaluated in gerbil models of cerebral ischemia. Following temporary bilateral carotid occlusion, hypotension was transiently reversed by these endorphin antagonists. However, neither drug altered time to awaken, time to death,...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90419-2
更新日期:1982-07-26 00:00:00
abstract::Insulin binding and 3-0-Methylglucose transport have been studied in erythrocyte- and reticulocyte-enriched fractions of blood cells in order to determine if the increased number of insulin binding sites in reticulocytes is associated with a glucose transport response to insulin. In these experiments rabbit reticulocy...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90588-4
更新日期:1982-07-19 00:00:00
abstract::Kainic acid (KA) is a potent convulsant which, when administered subcutaneously, induces sustained limbic seizures and a pattern of limbic brain damage that is thought to be seizure-mediated. Diazepam suppresses and morphine enhances both the seizures and brain damage induced by KA. Here we show that morphine enhancem...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90582-3
更新日期:1982-07-19 00:00:00
abstract::In vitro studies showed that organophosphate insecticides have different IC50 values (i.e., concentration of inhibitor required to inhibit 50% enzyme activity) for acetylcholinesterases (AChE's) from different species. Since previous reports indicated that the binding of active cholinesterase inhibitors to non-critica...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90426-x
更新日期:1982-07-12 00:00:00
abstract::Bovine brain phospholipid liposomes (BC-PL) reduce plasma prolactin (PRL) levels in humans after acute administration and counteract the metoclopramide- and sulpiride-induced hyperprolactinaemia. However, BC-PL, like nomifensine, a dopamine (DA) reuptake inhibitor and therefore an indirect dopaminergic compound, does ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90395-2
更新日期:1982-07-05 00:00:00
abstract::The effect of gamma-aminobutyric acid (GABA) on the binding of PK 8165, a quinoline derivative, and CGS 8216, a pyrazoloquinoline, was assessed in two different regions of the rat brain. PK 8165, a compound with reported anxiolytic properties, inhibited [3H]-propyl beta-carboline-3-carboxylate labeled receptors in the...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90403-9
更新日期:1982-07-05 00:00:00
abstract::This study was undertaken to compare the activity of muscarinic and beta adrenergic receptors in bovine peripheral lung to the corresponding receptor activity in tracheal smooth muscle. We used [3H] quinuclidinyl benzilate (QNB) and [3H]dihydroalprenolol (DHA) to measure muscarinic and beta receptor activity, respecti...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90449-0
更新日期:1982-06-14 00:00:00
abstract::Voltage clamp recordings of GH3/B6 pituitary cells reveal the presence of non linear steady state membrane properties at the level of the resting potential (about -41 mV). Clamping the cells to potentials more depolarized than -60 mV is associated with a potential dependent increase in membrane conductance and membran...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90475-1
更新日期:1982-05-31 00:00:00
abstract::The characteristics and distribution of putative thyrotropin releasing hormone (TRH) receptors were studied in rat central nervous system using the TRH analogue 3H-(3MeHis2)TRH as a radiolabeled ligand. The analogue had a dissociation constant of 2.3 +/- 0.2 nM and a receptor density of 34 +/- 2 fm/mg protein in whole...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90315-0
更新日期:1982-05-24 00:00:00
abstract::Juncusol, phenolic compound, was isolated from the black needlerush, Juncus roemerianus. Different concentrations of this extract were tested for toxicity against selected species of estuarine fish and grass shrimp. Juncusol was ten times more toxic to the various species of fish than to grass shrimp. At 2.0 ppm conce...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90317-4
更新日期:1982-05-24 00:00:00
abstract::The effects of nineteen AHPA* derivatives were examined on morphine analgesia by tail-flick test in rats and on enkephalinase inhibition which was based on the formation of tyrosyl-glycyl-glycine from met-enkephalin. The correlation between the enhancement of morphine analgesia in vivo and enkephalinase inhibition in ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90308-3
更新日期:1982-05-17 00:00:00
abstract::Partially purified fractions from sheep pineal gland extracts, which show a fluorescence like pteridines, were shown to suppress the enzyme hydroxy-indole-o-methyltransferase (HIOMT) isolated from avian pineals and retinas. The results described demonstrate that the mechanism of inhibition of HIOMT activity is indepen...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90022-4
更新日期:1982-04-19 00:00:00
abstract::Three continuous cell lines isolated from small cell carcinoma of the lung (SCCL) have been examined for their ability to take up and metabolize the biogenic amine precursors, L-DOPA and 5-hydroxytryptophane (5-HTP). In two of the three lines formaldehyde-induced fluorescence (FIF) and mass-spectrographic analysis ind...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90020-0
更新日期:1982-04-19 00:00:00
abstract::Neonatally androgenized (NA) female rats were ovariectomized (OVX) as adults and given 1 mg of testosterone propionate/day for 7 days and the plasma prolactin (PRL) pattern compared with NA intact animals and normal OVX animals given estrogen or TP. NA intact animals had elevated basal (morning values) and an attenuat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90663-4
更新日期:1982-04-05 00:00:00
abstract::The role of dopamine (DA) input on the activity of glutamate neurons was investigated on rat striatal and cortical tissue using the measurement of sodium-dependent high affinity glutamate uptake (HAGU) as an index. Incubation of the tissue in the presence of DA, apomorphine or bromocriptine produced marked inhibition ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90658-0
更新日期:1982-04-05 00:00:00
abstract::The relationship between prolactin (PRL) secretion and the neurointermediate lobe (NIL) of the pituitary gland was investigated. Plasma PRL concentrations in rats bearing anterior pituitaries autografted with or without the NIL to the renal capsule were elevated to equal extents at 1 through 6 weeks after surgery (p g...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90535-5
更新日期:1982-03-29 00:00:00
abstract::Methotrexate was found to stimulate asparagine synthetase activity in vivo by approximately six-fold in rat liver. The maximum effect of methotrexate on hepatic asparagine synthetase activity was observed sixteen hours after intraperitoneal injection of the drug. Cycloheximide, like methotrexate, is a protein synthesi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90524-0
更新日期:1982-03-22 00:00:00
abstract::Two alpha-adrenoceptor antagonists, phentolamine and 2-(beta-(4-hydroxyphenyl)-ethylaminomethyl)-tetralone (BE 2254) which are phenolic derivatives were radioiodinated after chloramine-T oxidation of Na125I and the labelled material isolated by chromatography. 125I-phentolamine does not bind selectively to alpha-adren...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90623-3
更新日期:1982-03-15 00:00:00
abstract::The effect of fluoride ion on the binding of the specific muscarinic agonist ligand [3H]cis methyldioxolane ([3H]CD) to the mouse cardiac muscarinic receptor was investigated. Utilizing equilibrium ligand binding experiments, sodium fluoride (10mM) was shown to decrease [3H]CD binding, measured at a concentration of 2...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90602-6
更新日期:1982-03-08 00:00:00
abstract::Rats with experimental allergic encephalomyelitis (EAE) induced with myelin or spinal cord show decreases in the content of sulphatides and cerebrosides and increases in the level of esterified cholesterol in the CNS. In this work it is shown that brain sulphatide changes can be obtained by injection of mixtures conta...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90600-2
更新日期:1982-03-08 00:00:00
abstract::14C-Imipramine was administered to male and female Sprague-Dawley rats and animals were sacrificed at 4, 8, 12, and 20 hours later. At all time points, total radioactivity in female lung was several-fold higher than in males. In addition, female lungs had a higher concentration of desmethylimipramine (DMI) as compared...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90610-5
更新日期:1982-03-01 00:00:00
abstract::An increase in the weight of the thyroid gland, accompanied by reductions in uptake and release of 1311, serum T3 and reverse T3 concentrations and an increase in serum TSH concentration, occurs during the development of renal hypertension in rats. Renal function, as assessed by BUN, serum and urinary creatinine conce...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90274-0
更新日期:1982-02-15 00:00:00
abstract::Renal compensatory hypertrophy (RCH) occurs in hypothyroid rate, but it is impaired when compared to RCH found in euthyroid controls. It is due to cellular hypertrophy as the DNA content does not change and the Protein/DNA ratio increases in the compensating kidney. RCH is enhanced by thyroxine (T4) with a rise in the...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90278-8
更新日期:1982-02-15 00:00:00
abstract::Rats, trained to discriminate 1.5 mg/kg of the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a two-lever drug discrimination task, were challenged with various doses of the 4-methoxy, 4-methylthio and 5-methylthio derivatives of DMT. The 5-OMe DMT cue was found to generalize to all t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90463-5
更新日期:1982-02-01 00:00:00
abstract::Virgin, male Sprague-Dawley rats were used to study the production of cardiac failure by a single subcutaneous injection of 85 mg/kg dl-isoproterenol (ISO) and the possible preservation of cardiac function by a pre-treatment of 50 mg/kg verapamil (VER) 5 min prior to 85 mg/kg ISO. At 24 hrs after drug injections cardi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90512-4
更新日期:1982-01-18 00:00:00
abstract::Antinuclear antibodies (ANA) development was studied in male guinea pigs in response to chronic treatment with procainamide, hydralazine, acetanilide or caffeine. Acetanilide and caffeine have not previously been associated with ANA induction. Fifty-one weanling Hartley guinea pigs were divided into five groups which ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90653-1
更新日期:1982-01-11 00:00:00
abstract::Ozone is a highly efficient disinfectant which may have significant advantages in water treatment compared to chlorine. It has, however, been shown that mutagenic and possibly carcinogenic byproducts may be produced under certain conditions of ozonation. Light chlorination following ozonization may meet the highest st...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(82)90643-9
更新日期:1982-01-11 00:00:00
abstract::In order to determine whether CCl4, CBrCl3, CBr4 or CHCl3 undergo oxidative metabolism to electrophilic halogens by liver microsomes, they were incubated with liver microsomes from phenobarbital pretreated rats in the presence of NADPH and 2,6-dimethylphenol. The analysis of the reaction mixtures by capillary gas chro...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90644-0
更新日期:1982-01-11 00:00:00
abstract::Four Rhesus monkeys were subjected to daily administration of 2.5 mg of tetrahydrocannabinol (THC)/kg body wt, after establishing the norms for complete blood count, T- and B-cell concentrations, and the dose response of thymidine incorporation after PHA stimulation. THC was administered daily for 3 weeks, the treatme...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90642-7
更新日期:1982-01-04 00:00:00